Toshinori Ito Selected Research

Colitis

1/2020	Sanguisorba officinalis L. derived from herbal medicine prevents intestinal inflammation by inducing autophagy in macrophages.
1/2015	Perilla frutescens extract ameliorates DSS-induced colitis by suppressing proinflammatory cytokines and inducing anti-inflammatory cytokines.
12/2013	Inhibition of epithelial cell death by Bcl-2 improved chronic colitis in IL-10 KO mice.
1/2011	Therapeutic effects of novel sphingosine-1-phosphate receptor agonist W-061 in murine DSS colitis.
1/2008	A novel sphingosine 1-phosphate receptor agonist, 2-amino-2-propanediol hydrochloride (KRP-203), regulates chronic colitis in interleukin-10 gene-deficient mice.
5/2007	Therapeutic effects of roxithromycin in interleukin-10-deficient colitis.
4/2005	Colitis in mice lacking the common cytokine receptor gamma chain is mediated by IL-6-producing CD4+ T cells.
5/2004	Therapeutic effects of a new lymphocyte homing reagent FTY720 in interleukin-10 gene-deficient mice with colitis.

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Toshinori Ito Research Topics

Disease

13	Neoplasms (Cancer) 08/2019 - 01/2002
12	Pain (Aches) 01/2016 - 08/2006
9	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 12/2021 - 07/2003
8	Colitis 01/2020 - 05/2004
8	Stomach Neoplasms (Stomach Cancer) 04/2016 - 06/2002
6	Low Back Pain (Lumbago) 01/2016 - 04/2006
5	Hyperalgesia 07/2009 - 08/2006
4	Brain Death (Brain Dead) 04/2021 - 01/2004
4	Inflammation (Inflammations) 12/2008 - 08/2006
4	Ganglion Cysts (Ganglion) 06/2008 - 08/2006
3	Crohn Disease (Crohn's Disease) 08/2016 - 12/2002
3	Infections 04/2016 - 12/2002
3	Surgical Wound Infection 04/2016 - 06/2013
3	Spinal Stenosis (Stenosis, Spinal) 01/2016 - 11/2012
3	Body Weight (Weight, Body) 06/2015 - 01/2008
3	Pancreatic Neoplasms (Pancreatic Cancer) 02/2014 - 03/2006
3	Intervertebral Disc Displacement (Herniated Disc) 07/2009 - 08/2006
2	Cognitive Dysfunction 01/2021 - 01/2020
2	Chronic Kidney Failure (Chronic Renal Failure) 07/2020 - 12/2019
2	Insulin Resistance 12/2019 - 06/2015
2	Thrombosis (Thrombus) 11/2016 - 07/2008
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 07/2016 - 06/2015
2	Wounds and Injuries (Trauma) 04/2016 - 09/2013
2	Neuralgia (Stump Neuralgia) 01/2016 - 01/2007
2	Graft vs Host Disease (Graft-Versus-Host Disease) 03/2012 - 01/2010
2	Ulcerative Colitis 09/2010 - 04/2006
2	Nerve Degeneration 09/2007 - 01/2007
2	Pathologic Constriction (Stenosis) 09/2007 - 01/2007
2	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 06/2007 - 01/2003
2	Neoplasm Metastasis (Metastasis) 08/2002 - 01/2002
1	Varicose Veins (Varicose Vein) 01/2022
1	Pancreatic Fistula (Pancreatic Fistulas) 12/2021
1	Diabetic Nephropathies (Diabetic Nephropathy) 12/2021
1	Neoplasms, Cystic, Mucinous, and Serous 12/2021
1	COVID-19 01/2021
1	Dementia (Dementias) 01/2020
1	Glucose Intolerance 12/2019
1	Melanoma (Melanoma, Malignant) 08/2019
1	Sarcopenia 10/2018
1	Colorectal Neoplasms (Colorectal Cancer) 01/2018
1	Pouchitis 08/2016
1	Malnutrition (Nutritional Deficiencies) 08/2016
1	Carcinogenesis 07/2016
1	Intermittent Claudication 01/2016

Drug/Important Bio-Agent (IBA)

8	CytokinesIBA 01/2015 - 04/2005
4	Peptides (Polypeptides)IBA 08/2019 - 06/2007
4	Therapeutic UsesIBA 08/2016 - 05/2004
4	Interleukin-10 (Interleukin 10)IBA 12/2013 - 05/2004
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 06/2008 - 04/2006
4	InterleukinsIBA 01/2008 - 01/2002
3	Insulin (Novolin)FDA Link 12/2021 - 01/2013
3	AdiponectinIBA 07/2016 - 01/2013
3	methanesulfonate salt 2-hydroxy-4,4'-diamidinostilbeneIBA 06/2008 - 12/2006
2	LipidsIBA 07/2016 - 08/2002
2	DNA (Deoxyribonucleic Acid)IBA 01/2014 - 03/2006
2	Biomarkers (Surrogate Marker)IBA 01/2014 - 01/2013
2	Proteins (Proteins, Gene)FDA Link 05/2012 - 04/2006
2	Sphingosine-1-Phosphate ReceptorsIBA 01/2011 - 01/2008
2	GAP-43 Protein (GAP 43 Protein)IBA 04/2010 - 06/2008
2	Fingolimod Hydrochloride (FTY720)FDA Link 01/2010 - 05/2004
2	Nerve Growth Factor (NGF)IBA 10/2009 - 12/2008
2	NF-kappa B (NF-kB)IBA 07/2009 - 12/2006
2	Freund's AdjuvantIBA 12/2008 - 08/2006
2	LectinsIBA 06/2007 - 01/2007
2	Interleukin-12 (IL 12)IBA 05/2007 - 01/2002
2	Paclitaxel (Taxol)FDA LinkGeneric 01/2003 - 01/2003
2	Contrast MediaIBA 01/2003 - 01/2002
1	Catechin (Z 7300)IBA 01/2020
1	villinIBA 01/2020
1	Gallic AcidIBA 01/2020
1	Ellagic AcidIBA 01/2020
1	ziyuglycoside IIIBA 01/2020
1	AcidsIBA 01/2020
1	Cell Wall SkeletonIBA 08/2019
1	imidazoleacetic acid (IMAC)IBA 10/2018
1	Panitumumab (Vectibix)FDA Link 01/2018
1	Cetuximab (Erbitux)FDA Link 01/2018
1	Infliximab (Remicade)FDA Link 08/2016
1	Capsules (Microcapsules)IBA 07/2016
1	Food IngredientsIBA 07/2016
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 07/2016
1	AntioxidantsIBA 03/2016
1	Prostaglandins BIBA 01/2016

Therapy/Procedure

11	Pancreas Transplantation 01/2022 - 01/2004
9	Therapeutics 02/2021 - 01/2007
7	Transplantation 02/2021 - 01/2010
5	Gastrectomy 04/2016 - 06/2002
4	Drug Therapy (Chemotherapy) 01/2020 - 01/2014
3	Immunotherapy 08/2019 - 07/2010
3	Kidney Transplantation 11/2016 - 07/2008
3	Aftercare (After-Treatment) 05/2014 - 07/2013
2	Pancreatectomy 12/2021 - 11/2016
2	Operative Surgical Procedures 04/2016 - 01/2009
2	Conservative Treatment 05/2014 - 07/2013
2	Islets of Langerhans Transplantation 01/2013 - 07/2003
2	Restorative Proctocolectomy 09/2010 - 04/2006
2	Laparotomy 07/2008 - 04/2006
1	Renal Dialysis (Hemodialysis) 12/2021
1	Pancreaticoduodenectomy 12/2021
1	Radiotherapy 03/2016